Fresh analysis suggests that patients who stop using popular weight-loss injections like Wegovy and Mounjaro can put back on shed pounds much more quickly than those who stop conventional lifestyle programs.
Published data in a prominent medical journal points out that while obese people frequently drop about a fifth of their total mass while using the jabs, the weight comes back at an average rate of nearly a kilo each month upon discontinuation.
"Individuals using these drugs need to be informed of the potential of rapid rebound weight gain when the treatment concludes," cautioned lead investigator Dr. Susan Jebb.
That rate of regain suggests a reversion to starting mass in about one and a half years.
Comparing Therapies
The study, which looked at dozens of trials involving thousands of patients, compared the results of the injectable medications with older methods.
Scientists emphasize that individuals who lose weight through dieting typically experience a slower creep back—approximately 0.1 kg a month—once they finish.
Explaining the Quick Regain
Experts suggest the mode of action of the jabs is key to understanding the amplified rebound.
The injections mimic a natural hormone called glucagon-like peptide-1, which controls hunger.
"Long-term administration of GLP-1 levels several times higher than normal might result in the body to produce less of its own natural hormone, and could lessen responsiveness to its effects," explained Dr. Adam Collins, a nutrition specialist.
"Withdrawal of this hormone supplement leads to appetite is no longer kept in check, making binge eating a significant risk."
A Chronic Disease?
The NHS advise the jabs for individuals with weight-linked health risks, alongside recommended diet and exercise modifications.
Professionals contend that, considering the significant potential of relapse, the treatment might need to be ongoing.
This view is supported by pharmaceutical companies, who note that the results "highlight the long-term character of excess weight," similar to managing diseases like diabetes.
User Accounts
People who have discontinued the jabs explain a powerful return of hunger.
"It felt as if something that goes on and you become starving," said an individual.
This difficulty is worsened if individuals have not adopted sustainable lifestyle or habit changes during treatment.
Significant Use
Figures indicate that a significant number of people in the UK have tried these injections in the last 12 months, with desire being substantial.
- Adoption is greater among women than males.
- The 40s and 50s age group shows the greatest level of interest.
- A large proportion access the drugs through private healthcare rather than public health services.
In conclusion, clinicians stress that while the jabs are powerful tools for shedding pounds, they are not a standalone solution and long-term success hinges on combined lifestyle support.
